2 edition of Early gene expression profile in mouse brain after exposure to clinically relevant doses of ionizing radiation. found in the catalog.
Early gene expression profile in mouse brain after exposure to clinically relevant doses of ionizing radiation.
Ashraf Shawky Mahmoud-Ahmed
Written in English
This data provides the basis for further research to delineate the role of novel genes in XRT-induced CNS injury. JAK3 will be studied as a potential neuro-protective target from XRT injury.The possibility of damaging the central nervous system (CNS) is a major problem in clinical radiation treatment (XRT). Using cDNA microarray, we studied global gene expression in mouse brain within 24 h following clinically relevant doses of XRT.Early response of mouse brain to XRT is a complex process that involves dose- and time-dependent expression of hundreds of genes and modulates different molecular functions and pathways. Genes involved in signal transduction, metabolism, structural proteins, transcription, and cell cycle were modulated by XRT in mouse brain. Using real time PCR, we confirmed changes in expression of DNA fragmentation factor, beta subunit, nuclease sensitive element binding protein 1, Janus kinase3 (JAK3), and Telomeric repeat binding factor 1. Upregulation of JAK3 expression was demonstrated by immunohistochemistry.
|The Physical Object|
|Number of Pages||153|
Arturo Rodriguez. Message from the President of the United States, transmitting a copy of an ordinance granted by the Executive Council of Porto Rico granting to Arturo Rodriguez the right to construct, maintain, and operate a system for the manufacture, distribution, and sale of gas for light, heat, and power purposes in the Municipality of San Juan.
Tourist map, Bangkok City
walk through time
French foreign policy since the Second World War.
Folk tales of Bangladesh
Before You Buy a Used Computer
No More Tomorrows
architecture of northern England
Competition and concentration in the EU banking industry
Diamond smuggling and taxation in Sub-Saharan Africa
RNA recognition by SAM domains
U.S. imports via minibridge
Forest tree nurseries in Washington and adjacent states
Because He Lives Bulletins
Symposium on Liquid-Liquid Extraction