Last edited by Malasar
Wednesday, August 5, 2020 | History

2 edition of Early gene expression profile in mouse brain after exposure to clinically relevant doses of ionizing radiation. found in the catalog.

Early gene expression profile in mouse brain after exposure to clinically relevant doses of ionizing radiation.

Ashraf Shawky Mahmoud-Ahmed

Early gene expression profile in mouse brain after exposure to clinically relevant doses of ionizing radiation.

by Ashraf Shawky Mahmoud-Ahmed

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Published .
Written in English


About the Edition

This data provides the basis for further research to delineate the role of novel genes in XRT-induced CNS injury. JAK3 will be studied as a potential neuro-protective target from XRT injury.The possibility of damaging the central nervous system (CNS) is a major problem in clinical radiation treatment (XRT). Using cDNA microarray, we studied global gene expression in mouse brain within 24 h following clinically relevant doses of XRT.Early response of mouse brain to XRT is a complex process that involves dose- and time-dependent expression of hundreds of genes and modulates different molecular functions and pathways. Genes involved in signal transduction, metabolism, structural proteins, transcription, and cell cycle were modulated by XRT in mouse brain. Using real time PCR, we confirmed changes in expression of DNA fragmentation factor, beta subunit, nuclease sensitive element binding protein 1, Janus kinase3 (JAK3), and Telomeric repeat binding factor 1. Upregulation of JAK3 expression was demonstrated by immunohistochemistry.

The Physical Object
Pagination153 leaves.
Number of Pages153
ID Numbers
Open LibraryOL19217267M
ISBN 100494073853


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Early gene expression profile in mouse brain after exposure to clinically relevant doses of ionizing radiation by Ashraf Shawky Mahmoud-Ahmed Download PDF EPUB FB2